Simpleware 2025.06 (X-2025.06) is the latest release of Synopsys' industry-leading software platform for 3D image processing, analysis, and model generation from medical and industrial imaging data (CT, MRI, micro-CT, etc.). Released in June 2025, this version introduces expanded third-party AI model support, CAD device libraries, enhanced auto-segmentation tools, and improved project organization .

Key New Features in X-2025.06

Third-Party AI Model Support

• nnU-Net Integration: Import and run externally trained nnU-Net AI segmentation models directly within Simpleware

• MONAI Bundle Support: Full compatibility with MONAI bundles for expanded AI workflow integration

• Custom Model Deployment: Deploy user-trained models to scale patient-specific workflows faster

Surface Design Library

• Customizable CAD/STL Database: Create a fully customizable library infrastructure for quickly accessible CAD/STL device models

• Component Validation: Swap different sizes of implant components to assess compatibility with patient anatomy

• Efficient Design Checking: Rapidly validate device configurations against anatomical structures

Enhanced Hip Revision CT Auto Segmentation

• Expanded One-Click Segmentation: Now includes cancellous bone segmentation for the femur bones

• Cortical Bone & Canal Modeling: Model cortical bone and/or the medullary canal for implant fitting or simulation workflows

Dataset Browser Folders

• Object Organization: Create folders for masks, surfaces, and volume meshes

• Project Tidyness: Keep project files organized by collecting objects into relevant groups or collections

Additional Enhancements

• Custom Coordinate Systems: Create, edit, and manage custom coordinate systems for measurements and surface objects

• X-Ray Usability: Further enhancements for interactive positioning and visual feedback

• NIfTI Export: New export format and scripting API support to enable more AI workflows

• FE/CFD Meshing: New CFD LS-Dyna .key format including Node Sets and Element Sets; define element/node/triangle sets within an FE part volume

• GUI Profiles: More example GUI profiles added for immediate use or inspiration

Core Capabilities

Image Processing & Segmentation

• Multi-Modality Support: Import data from CT, MRI, PET, micro-CT, and microscopy

• Auto Segmentation: AI-enabled tools for rapid anatomical structure identification

• Manual Segmentation: Advanced tools for precise region-of-interest definition

3D Modeling

• Surface Generation: Create watertight surfaces for CAD/3D printing

• Volume Meshing: Generate FE/CFD-ready volume meshes

• CAD Integration: Seamless data transfer with other Synopsys tools

Analysis & Quantification

• Measurements: Distance, angle, volume, and surface area calculations

• Simulation: Strain analysis, fluid flow simulations, and more

• Custom Workflows: Scriptable API for automated processing