LipidSearch 5.1 SP1: Automated Lipid Identification & Quantification Software

LipidSearch 5.1 SP1 is the latest version of Thermo Fisher Scientific's powerful software for automated lipid identification and relative quantification from LC-MS data. SP1 typically refers to Service Pack 1, which delivers performance enhancements, stability improvements, and bug fixes following the 5.1 release .

Key Features

Smart Peak Detection

• Instrument-Tailored Algorithms: Unique peak detection algorithms optimized for different MS experiment types and instrument platforms

• Accurate Detection: Ensures precise peak detection for better identification and quantification

Extensive Lipid Database

• >1.5 Million Lipid Ions: Comprehensive database of lipid ions and predicted fragment ions

• MSⁿ Fingerprints: Includes lipid adduct ions and MSⁿ fingerprint data

• Customizable: XML-based storage allows easy database customization

• Expanding Coverage: New lipid classes and fatty acids added for specialized sample types (skin, plant lipids)

Dual Identification Algorithms

• Group-Specific ID: Optimized for targeted identification using precursor ion and neutral loss scans based on polar head groups or fatty acids

• Comprehensive ID: Optimized for untargeted identification using product ion scans combined with database matching

• Scoring System: Algorithms prioritize most reliable lipid identifications

Peak Alignment for Quantitation

• Retention Time Alignment: Chromatographic peaks from each sample aligned within retention time windows prior to quantitation

• Accurate Relative Quantitation: Ensures more precise quantitative results