PEAKS Studio v12 is a powerful, all-in-one software platform for the comprehensive analysis of mass spectrometry-based proteomics data. It is renowned for its high-accuracy de novo sequencing engine and robust database search capabilities, enabling researchers to identify and characterize proteins with unparalleled depth. From simple protein identification to complex tasks like discovering post-translational modifications (PTMs), quantifying expression changes, and performing antibody de novo sequencing, PEAKS Studio provides an integrated workflow to transform raw LC-MS/MS data into meaningful biological understanding, driving discovery in disease research, drug development, and systems biology.

Core Functional Capabilities of PEAKS Studio v12

• High-Accuracy De Novo Sequencing
  Identify peptides without relying on a protein database. This powerful feature is critical for discovering novel proteins, sequencing antibodies, analyzing samples from organisms with unsequenced genomes, or validating database search results, providing sequence information where other methods fail.

• Comprehensive Database Search & PTM Discovery
  Perform sensitive and specific protein identification. PEAKS Studio can search against large databases while simultaneously performing PTM discovery, identifying hundreds of potential modifications like phosphorylation, glycosylation, and acetylation in a single, unbiased analysis.

• Label-Based & Label-Free Quantification
  Measure protein abundance changes across multiple samples. The software supports various quantification strategies, including tandem mass tag (TMT) and isobaric tags for relative and absolute quantitation (iTRAQ) for labeled experiments, as well as accurate label-free quantification (LFQ) for untargeted studies.

• Specialized Workflows: Antibody & HLA Peptidomics
  Access dedicated modules for advanced applications. PEAKS AB focuses on the complete characterization of monoclonal antibodies, including sequencing and PTM analysis. Other modules support the analysis of HLA-bound peptides for immunopeptidomics research.

The PEAKS Studio Advantage in Proteomics

In the complex field of proteomics, data analysis is often the bottleneck. PEAKS Studio v12 addresses this by combining multiple advanced analysis techniques into a single, user-friendly interface. Its strength in de novo sequencing provides a unique advantage for exploratory and challenging projects, while its integrated quantification and PTM tools offer a complete solution for differential expression studies. Trusted by core facilities and research labs worldwide, PEAKS Studio empowers scientists to extract the maximum amount of information from their mass spectrometry experiments, accelerating the path from data to discovery.